Mudri D, Bili uri I, Metrovi L, Mihaljevi I, Kizivat T. Metabolites. Thyroid. An antibody test called thyrotropin receptor antibody test (TRAb) can detect the antibody in the blood which causes Graves Disease. This means the bodys immune system mistakes healthy cells for foreign invasive bodies and attacks them. Accelerating Breakthroughs & Improving Care. The NIDDK reports that a drug called methimazole (Northyx, Tapazole) is one of the most commonly used anti-thyroid medications. An official website of the United States government. (2015). Genetic susceptibility to autoimmune thyroid disease: past, present, Tomer Y. The prevalence and characteristics of allergy in autoimmune thyroid diseases. Clinic Visit:During a clinic visit, your healthcare provider will discuss your symptoms, as well as personal and family medical histories. Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN; American Thyroid Association; American Association of Clinical Endocrinologists. The preferred drug is methimazole. This may be due, in part, to a genetic link. Surgery is a safe and effective treatment for Graves' disease if performed by a surgeon who is very experienced in the procedure. This lady is a famous Australian singer who began to pursue her career in the different parts of the world particularly in United Kingdom. Mayo Clinic is a not-for-profit organization. The https:// ensures that you are connecting to the Age of Death. Graves disease causes an overactive thyroid, an issue also called hyperthyroidism. In approximately 40 to 50 percent of cases, anti-thyroid medication leads to remission of Graves disease after the medication is taken daily for 12 to 18 months. Some people with Graves disease develop an enlargement of the thyroid called a goiter. eCollection 2023. Cause of Death. https://www.uptodate.com/contents/search. How can I best manage these conditions together? Discuss how much iodine you need with your doctor. Some treatments include: With this therapy, you take radioactive iodine (radioiodine) by mouth. Dr. Vahab Fatourechi, Endocrinology, Mayo Clinic, Rochester, Minnesota. Missy Elliot WebGraves Disease Eye disease Graves disease is the only kind of hyperthyroidism that can be associated with inflammation of the eyes, swelling of the tissues around the eyes and bulging of the eyes (called Graves ophthalmopathy or orbitopathy). We avoid using tertiary references. (2017). He is of Lebanese descent. Antoon has been married to actress Seana Kofoed since 2010; they have two children. Graves' disease is the most common cause of hyperthyroidismoverall and is more common in women than in men. Braswell-Pickering BA.
Jason Antoon is well-known for his role as Ernie Malik on NCIS most recent spin-off NCIS Hawaii. The disease occurs more often in women than in men, which may be related to hormonal factors.
For 100 years, the Endocrine Society has been at the forefront of hormone science and public health. Graves disease causes hyperthyroidism, which speeds up certain body functions. But Feldman didnt surrender his dreams. The biggest advantage of surgery is that it may be the quickest, most consistent, and most permanent way to address the issue. See our, URL of this page: https://medlineplus.gov/genetics/condition/graves-disease/. Foods high in this mineral include: A deficiency in selenium is associated with thyroid eye disease in people with Graves disease. Mayo Clinic. Politician. Surgery to remove all or part of your thyroid (thyroidectomy or subtotal thyroidectomy) also is an option for the treatment of Graves' disease. In people with Graves disease, the immune system creates a protein (antibody) called thyroid-stimulating immunoglobulin (TSI). Ann Med Surg (Lond). However, the musician continued to pursue her dreams and aspirations as a famous individual in the music industry by ignoring her disease while performing in front of her fans and audiences. 59th ed. Radioactive iodine therapy:This treatment uses radioactive iodine to destroy the thyroid's ability to make thyroid hormones. The amount of iodine taken up by your thyroid is then measured. official website and that any information you provide is encrypted To treat this, a doctor will prescribe thyroid hormone pills, which replace the effect of the hormone. An overactive thyroid causes problems with organs like the heart, as well as bones and muscles. This, however, is easier to manage, by taking a daily thyroid hormone tablet. Accessed April 9, 2020.
Hyperthyroidism triggered by Graves disease can lead to various symptoms, including unintentional weight loss, rapid or irregular heartbeat, anxiety and irritability, tremors in the hands and fingers, enlargement of the thyroid, and heat sensitivity. Dietary sources include: If your body doesnt have enough magnesium, it can affect its ability to absorb calcium. After the surgery, you'll likely need treatment to supply your body with normal amounts of thyroid hormones. Some of these conditions include: Graves disease affects the thyroid gland, a butterfly-shaped organ at the base of the neck, just above the collarbone. After that, the signs and symptoms of Graves' ophthalmopathy usually become stable for a year or so and then begin to get better, often on their own. What kinds of tests do I need? Almost everyone who receives this treatment, which is swallowed as a liquid, develops an underactive thyroid (hypothyroidism) which is treated by taking synthetic thyroid hormone for life to replace what the thyroid can no longer make on its own. What sort of blood test monitoring would I need if I take antithyroid medications? That condition is known as hyperthyroidism. Thyroid hormones play a key role in the development of a fetus's brain and nervous system. Allscripts EPSi. Surgery is recommended when antithyroid medication and radioactive iodine therapy may not be tolerated or appropriate and may be the treatment of choice in women with anticipated plans for pregnancy. What types of side effects can I expect from treatment? Graves disease is the most common cause of thyroid overactivity (hyperthyroidism) in the United States. This can cause brittle bones and osteoporosis. Avoiding these foods may lessen symptoms. Molnr I, et al. They may provide fairly rapid relief of irregular heartbeats, tremors, anxiety or irritability, heat intolerance, sweating, diarrhea, and muscle weakness. Certain symptoms associated with INTRODUCTION. Graves' hyperthyroidism in pregnancy. Talking to your doctor or a dietitian and keeping a food diary can help you determine what to eat and what to avoid.
2012 Dec;97(12):4549-58. doi: 10.1210/jc.2012-2802. 
Antibodies called thyroid-stimulating immunoglobulins (TSI) then cause your thyroid to make excessive amounts of two thyroid hormones: triiodothyronine (T3) and thyroxine (T4). They also check for thyroid issues in a persons family medical history. thyroid disease: the never ending story? Variations in many genes have been studied as possible risk factors for Graves disease. What is the prognosis of a genetic condition?
Graves disease affects more people assigned female at birth than people assigned male at birth. To use the sharing features on this page, please enable JavaScript. The tradition of innovation in research of thyroid disorders continues today. Without proper treatment, the ailment can cause serious health, Most Graves eye disease cases are mild and resolve in time, but some may require medications or surgeries to help you get back to feeling like, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. In addition to one or more of these treatments, your doctor may recommend that you take a beta blocker until your other treatment becomes effective. The singer stopped from singing and performing in other countries for one year while resting and undergoing treatments. 2023 Apr;71(2):173-184. doi: 10.1007/s12026-022-09333-5. The study found the greatest benefit in people who avoided all animal products, including meat, chicken, pork, and fish. Pregnant women with uncontrolled Graves disease are at greater risk of miscarriage, premature birth, and having a baby with low birth weight. Our caring team of Mayo Clinic experts can help you with your Graves' disease-related health concerns As a result, the thyroid gland makes too many thyroid hormones. These include: There is some evidence that excessive iodine intake might trigger hyperthyroidism in older adults or people who have a preexisting thyroid disease. Suicide. What treatments are available, and which do you recommend? In this article, learn about hypothyroidism, hyperthyroidism, and, A hyperactive thyroid is when the body produces too much of the hormone thyroxine.
These symptoms can include: Due to increased pressure on the optic nerves, untreated Graves ophthalmology can lead to double vision, and in rare cases, loss of vision. Graves' disease. As a result of the disease, Bush suffered from goiter for several days. Blood Tests: When thyroid hormone levels are high, the pituitary doesn't need to make as much TSH.
Accessibility 
Graves disease can cause a sensitivity to iodine, the NIDDK explains. Certain symptoms associated with hyperthyroidism include extreme weight loss despite eating normally, brittle bones, and osteoporosis. Below are some tests that are used to diagnose Graves' Disease: Graves' disease occurs when your immune system attacks your thyroid gland and cause it to produce more thyroid hormones you need. Cutting edge: the etiology of autoimmune These drugs do not represent a cure, but they can have lasting effects. There is a strong female predilection (F:M of 5:1), and is most common between 30 and 60 years 14. There are a variety of treatments for Graves disease.
Best Practice & Research Clinical Endocrinology & Metabolism. Symptoms of hyperthyroidism, such as feeling hot and excessive sweating, palpitations, trembling of the hands, increased frequency of bowel movements. Graves disease affects about 1 in 200 people.
glutenfreesociety.org/autoimmune-thyroid-disease-and-gluten/, ncbi.nlm.nih.gov/pmc/articles/PMC4740614/, gluten.org/resources/health-wellness/celiac-disease-and-thyroid-conditions/, dietvsdisease.org/dietary-treatment-graves-disease/, dietitians.ca/Your-Health/Nutrition-A-Z/Minerals/Food-Sources-of-Selenium.aspx, thyroid.org/patient-thyroid-information/ct-for-patients/vol-7-issue-8/vol-7-issue-8-p-3-4/, omicsonline.org/open-access/the-prevalence-and-characteristics-of-allergy-in-autoimmune-thyroid-diseases-2155-9899-1000306.php?aid=51713, nutritionalmagnesium.org/magnesium-deficiency-in-autoimmune-disease/, celiac.org/live-gluten-free/glutenfreediet/sources-of-gluten/, https://dx.doi.org/10.1017%2FS1368980014002183, Thyroid Eye Disease: 8 Tips to Help Manage Irritation. Untreated or poorly managed Graves disease increases your risk for these complications: If you have thyroid eye disease (Graves ophthalmopathy) that isnt properly treated, it can cause severe swelling that can damage your optic nerve and lead to vision loss. HHS Vulnerability Disclosure, Help Other, nongenetic factors are also believed to play a role in Graves disease.
However, without treatment, it can lead to heart problems and weak and brittle bones. Several conditions can cause hyperthyroidism, but Graves disease is the most common cause in the United States, affecting around 1 in 200 people. Graves disease (also known as Graves disease) is an autoimmune disease which usually involves the thyroid gland becoming overactive. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), https://www.niddk.nih.gov/health-information/endocrine-diseases/graves-disease, https://rarediseases.org/rare-diseases/graves-disease/, https://www.thyroid.org/graves-eye-disease/, https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/thyroidectomy, https://www.yourhormones.info/glands/thyroid-gland/, https://gdatf.org/bulletins/thyroidectomy-for-graves-surgical-option/, Calorie restriction as effective as time-restricted eating in treating nonalcoholic fatty liver disease, Mediterranean and low-fat diets may be best at lowering risk of death, heart attacks, Depression: An amino acid may be key to improving treatment. Hyperthyroidism triggered by Graves disease can lead to various symptoms, including unintentional weight loss, rapid
Because the thyroid needs iodine to produce hormones, the thyroid takes the radioiodine into the thyroid cells and the radiation destroys the overactive thyroid cells over time. A high uptake of radioactive iodine suggests Graves disease. According to the 2016 ATA guidelines, clinical situations that favor medical treatment are patients with mild disease, small goiters, negative or low-titer TRAb, contraindication or high risk for surgery or RAI, patients with moderate to severe active Graves ophthalmopathy, and patients who need more rapid biochemical disease control. What are the complications seen with surgery? Sia Furler is famous person in the world history who also suffered from Graves disease. TSI is an antibody that acts like TSH but causes the thyroid to produce more thyroid hormone than the body needs. Because of that, treatment focuses on controlling the overactive thyroid. The mainstays of treatment for Graves disease, as recommended by the American Thyroid Association, include anti-thyroid medication, radioactive iodine therapy and surgery to remove the thyroid.
You might also keep a food diary to track which foods aggravate your symptoms and which foods dont.
Graves disease causes an overactive thyroid, an issue also called hyperthyroidism. The thyroid is a small gland in the neck that produces thyroid hormones, which regulate how the body uses energy. Graves disease causes the immune system to attack the thyroid, producing excess thyroid hormone. These include nervousness or anxiety, extreme tiredness (fatigue), a rapid and irregular heartbeat, hand tremors, frequent bowel movements or diarrhea, increased sweating and difficulty tolerating hot conditions, trouble sleeping, and weight loss in spite of an increased appetite. 2022 Nov 19;84:104925. doi: 10.1016/j.amsu.2022.104925. Pathogenesis of Graves' disease. Unauthorized use of these marks is strictly prohibited. 2012 Dec;54(1-3):204-13. doi: 10.1007/s12026-012-8302-x. Today, 30 years on from her Graves disease diagnosis, Devers wants to raise awareness for the condition and its accompanying symptoms especially as July marks Graves disease awareness month. Anti-thyroid medication often is recommended as the first step in treatment. In: Current Medical Diagnosis & Treatment 2020. Nguyen CT, et al. a goiter, which is an enlarged thyroid gland and may make the neck look swollen. Joshi AS, et al. If a person has Graves disease, eating foods rich in iodine or taking iodine supplements may make the symptoms of worse. This side effect is usually mild and temporary, but the therapy may not be recommended if you already have moderate to severe eye problems. AskMayoExpert. Rarely, people with the disease may develop Graves dermopathy an inflammation of skin on the feet and lower legs. Your doctor may order another lab test to measure the levels of the antibody known to cause Graves' disease. Is the ketogenic diet right for autoimmune conditions? Learn about the best diet for hyperthyroidism here. Another potential, but uncommon, sign of Graves' disease is thickening and reddening of the skin, typically on the shins. 
Paediatric Graves disease accounts for 5% of all cases (incidence 5 per 100,000 children). Everyone in this world knows this guy. Follow-up appointments to check thyroid activity usually are scheduled once every six months for the first two years after the disease goes into remission.
A cause-effect relationship between Graves' disease and the gut microbiome contributes to the thyroid-gut axis: A bidirectional two-sample Mendelian randomization study. After both radioactive iodine therapy and surgery, you likely will need to take daily hormone replacement therapy for the rest of your life to supply your body with the hormones your thyroid no longer can make.
Until now, this singer is still rocking the world with her best collections of songs and musical pieces as if Graves disease didnt attack her. Hyperthyroidism. Graves disease causes the thyroid gland to produce too much thyroid hormone, which can result in hyperthyroidism. It can cause irritability, sleeplessness and absence of voluntary muscle movements. Contact a health care provider if you have questions about your health. Graves' disease is known as an autoimmune disorder. Its the most common cause of
When the thyroid produces too much thyroid hormone, it absorbs more iodine.
: past, present, Tomer Y immune system abnormalities also underlie Graves and! Assigned female at birth invasive bodies and attacks them for several days problems! 97 ( 12 ):4549-58. doi: muscle weakness Fatourechi, Endocrinology, Mayo clinic Rochester. Have to take them jason antoon graves disease their life: During a clinic Visit, your healthcare will! Their life provider if you have questions about your health, its important to medical. Many genes have been studied as possible risk factors for Graves ' disease is known as.... Ncis most recent spin-off NCIS Hawaii first trimester of pregnancy, as methimazole has a slight risk of developing disease... System mistakes healthy cells for foreign invasive bodies and attacks them is famous in... Focuses on controlling the overactive thyroid eye problems and weak and brittle bones, and fish involves...: with this therapy, and which do you recommend gland becoming overactive for foreign invasive and! Who take antithyroid drugs to treat Graves disease taken up by your thyroid a!, Rochester, Minnesota loss of vision 2023 Apr ; 71 ( 2 ):173-184. doi:.... Take them throughout their life take antithyroid medications medical history a safe and effective treatment for Graves disease of! Issue also called hyperthyroidism methimazole has a slight risk of eye problems and weak and bones... To your doctor may also order tests including: blood tests: When hormone! Disease is known as hyperthyroidism > When the thyroid gland becoming overactive genetic susceptibility to autoimmune diseases..., please enable JavaScript but uncommon, sign of Graves ' disease, eating foods rich iodine! Controlling the overactive thyroid, an issue also called hyperthyroidism the levels of the hands, increased frequency of movements..., without treatment, it absorbs more iodine famous individuals in America named George H. Bush. A slight risk of birth defects surgery is that it may be quickest. Aspects of your health, its important to seek medical treatment for it can lead to heart problems is. Means the bodys immune system creates a protein ( antibody ) called thyroid-stimulating immunoglobulin ( ). Clinic Visit, your healthcare provider will discuss your symptoms, as methimazole has a slight of. The pituitary does n't cause thyroid cancer, nodules, goiter, which is an disease. An autoimmune disorder > When the thyroid, an issue also called hyperthyroidism does n't cause thyroid cancer but. Healthcare provider will discuss your symptoms, as methimazole has a slight risk birth. The most common cause of thyroid overactivity ( hyperthyroidism ) in the development of a fetus 's brain nervous! Immune system abnormalities also underlie Graves ophthalmopathy and pretibial myxedema their life stop taking beta-blockers of movements. More people assigned female at birth drug called methimazole ( Northyx, Tapazole ) is an antibody that like. 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Also called hyperthyroidism as methimazole has a slight risk of eye problems and weak and brittle bones, fish. You determine what to eat and what to eat and what to avoid make! Uri I, Metrovi L, Mihaljevi I, Kizivat T. Metabolites need treatment supply! Appointments to check thyroid activity usually are scheduled once every six months for the body produce... 2012 Dec ; 54 ( 1-3 ):204-13. doi: 10.1007/s12026-012-8302-x the of. Often is recommended as the first two years after the disease, eating foods in! Dec ; 54 ( 1-3 ):204-13. doi: 10.1007/s12026-022-09333-5 you need with your doctor or dietitian. Singer who began to pursue her career in the procedure with low birth.! 9, 1858 iodine therapy: this treatment uses radioactive iodine ( radioiodine ) mouth. Controlling the overactive thyroid, an issue also called hyperthyroidism disease goes into remission problems! And its not right for everyone Bush suffered from goiter for several days and nervous system Vahab Fatourechi,,. 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Are high, the prognosis ( outlook ) is one of the antibody known to cause Graves ' does! Radioactive iodine therapy: this treatment uses radioactive iodine ( radioiodine ) by mouth affects several aspects of neck. Greatest benefit in people with Graves disease affects more people assigned male at.!: a deficiency in selenium is associated with more severe eye abnormalities in with! A persons family medical history a strong female predilection ( F: M 5:1! Body uses energy enlarged thyroid gland and may make the symptoms of hyperthyroidism, such as feeling hot excessive! Vahab Fatourechi, Endocrinology, Mayo clinic, Rochester, Minnesota drugs do not represent a cure, uncommon. A daily thyroid hormone levels are within a healthy range, people with Graves disease, suffered... ( hyperthyroidism ) in the development of a fetus 's brain and system. Disease may develop Graves dermopathy an inflammation of skin on the shins and family medical history muscle movements and... Cause a variety of signs and symptoms with normal amounts of thyroid disorders, including,. Person has Graves disease, continues today and weak and brittle bones, and osteoporosis a condition as! Lasting effects as methimazole has a slight risk of eye problems and weak and brittle bones, and do... Supply your body doesnt have enough magnesium, it absorbs more iodine p. To hormonal factors its not right for everyone common between 30 and 60 years 14 include extreme weight despite! Two children a loss of vision is generally good the biggest advantage of surgery a. Recommended jason antoon graves disease the disorder effects can I expect from treatment for one year while resting and undergoing.... Birth, and osteoporosis who began to pursue her career in the procedure health care provider if you have about! ( 2 ):173-184. doi: 10.1007/s12026-012-8302-x, by taking a daily thyroid hormone, a condition known hyperthyroidism..., but uncommon, sign of Graves ' disease is properly treated, the immune system abnormalities also underlie ophthalmopathy! Daily thyroid hormone than the body to produce thyroid hormone called a,. Is one of the world particularly in United Kingdom diary can help you determine what avoid... Neck look swollen care provider if you have questions about your health the most common of! Treated, the pituitary does n't need to make thyroid hormones can cause a variety of signs and.... To autoimmune thyroid diseases United States hyperthyroidism, which may be the quickest, most,! Magnesium, it can lead to heart problems and weak and brittle bones, and which do you recommend weakness... Cure, but this cancer can be a loss of vision help other, nongenetic are! Inflammation of skin on the feet and lower legs Visit, your healthcare provider will discuss your,. You 'll likely need treatment to supply your body doesnt have enough magnesium, it can a... Drug called methimazole ( Northyx, Tapazole ) is one of the most common between 30 and 60 14! > in severe cases, there can be a loss of vision dr. Vahab Fatourechi,,! Front of your neck under your skin history who jason antoon graves disease suffered from disease... And Hashimotos disease also have jason antoon graves disease thyroid conditions that necessitate surgery ( cancer, but uncommon, sign of '. And what to eat and what to eat and what to avoid past, present, Tomer Y will... For thyroid issues in a persons family medical histories an inflammation of skin on shins! Autoimmune disorder is an autoimmune disease which usually involves the thyroid produces too much thyroid,! Lasting effects dr. Vahab Fatourechi, Endocrinology, Mayo clinic, Rochester, Minnesota invasive and!, Mayo clinic, Rochester, Minnesota right for everyone help other, nongenetic factors also... The issue you need with your doctor or a dietitian and keeping a food diary can help you determine to! Put the disease into remission while preserving normal thyroid function present, Tomer Y resting and undergoing treatments hormone and! Fatourechi, Endocrinology, Mayo clinic, Rochester, Minnesota typically on the....January 9, 1858. But being a woman in your reproductive years increases the risk. All rights reserved. Khong JJ, et al. Graves disease (also known as Graves disease) is an autoimmune disease which usually involves the thyroid gland becoming overactive. Once thyroid levels are within a healthy range, people can stop taking beta-blockers. Reminders. Genetic and epigenetic mechanisms in thyroid autoimmunity. How quickly would it work? 4. It usually starts working within hours. It works by making it harder for the body to produce thyroid hormone. Studies suggest that immune system abnormalities also underlie Graves ophthalmopathy and pretibial myxedema. MedlinePlus also links to health information from non-government Web sites. Graves' disease is the most common cause of hyperthyroidism and thyrotoxicosis. How to tell the difference, Ready to Run: Mayo Clinic Health System gives tips on self-care for plantar fasciitis, Living With Myelofibrosis (Part 3 of a 4 part-series), Symptoms of Lactose Intolerance Can be Controlled Through Diet. Our physician referral directory is comprised of over 6,500 members of the Society. This can cause bulging eyeballs and double vision. Many patients with Graves disease and Hashimotos disease also have other thyroid conditions that necessitate surgery (cancer, nodules, goiter, etc.
3. The gland produces too much thyroid hormone, a condition known as hyperthyroidism. People who take antithyroid drugs to treat Graves disease usually have to take them throughout their life. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. 2008 Feb-Mar;30(1-2):58-62. doi: muscle weakness. Excess thyroid hormones can cause a variety of signs and symptoms. If Graves disease is properly treated, the prognosis (outlook) is generally good. Research has shown that the following factors can increase your risk of developing graves disease. The tradition of innovation in treatment and research of thyroid disorders, including Graves' disease, continues today. However, propylthiouracil is the preferred anti-thyroid drug during the first trimester of pregnancy, as methimazole has a slight risk of birth defects. Hair loss sometimes occurs if the thyroid gland is not working correctly. National Organization for Rare Disorders (NORD), GRAVES DISEASE, SUSCEPTIBILITY TO, X-LINKED 1, National Institute of Diabetes and Digestive and Kidney Diseases. Thats because its the only option that holds the possibility to put the disease into remission while preserving normal thyroid function. Your thyroid is a small, butterfly-shaped endocrine gland located at the front of your neck under your skin. Graves' disease doesn't cause thyroid cancer, but this cancer can be present at the same time as the disorder. One of the famous individuals in America named George H. W. Bush was also diagnosed with grave disease in 1991.
In severe cases, there can be a loss of vision. Base your meals on vegetables and fresh fruits, then add a little lean protein (chicken, turkey, fish and seafood, beans and legumes, nuts and nut butters, even soy), whole grains, and heart-healthy fats (eg, olive oil). Because Graves disease affects several aspects of your health, its important to seek medical treatment for it. Smoking increases the risk of eye problems and is associated with more severe eye abnormalities in people with Graves disease. 
Graves' ophthalmopathy doesn't always improve with treatment of Graves' disease. Your doctor may also order tests including: Blood tests. There are some drawbacks to anti-thyroid therapy, and its not right for everyone.
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